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Enzymatic debridement is best performed using collagenase because it is a specific agent that breaks down collagen in necrotic tissue, effectively promoting wound healing by facilitating the removal of devitalized tissue. Collagenase selectively targets the non-viable tissue without harming healthy cells, making it a preferred method in the management of chronic wounds.

The use of collagenase allows for a more controlled and less painful debridement process compared to other methods, such as mechanical debridement, which can cause trauma to surrounding tissues. It is particularly beneficial when additional procedures are not feasible or when the wound is too delicate for aggressive methods.

In contrast, saline solution does not actively promote debridement but can be used to hydrate and cleanse the wound. While antimicrobial ointments are essential in preventing infection, they do not address the need for the physical removal of necrotic tissue. Frequent dressing changes can help keep the wound clean and maintain a moist environment but do not contribute to enzymatic debridement specifically.